Pauline Hanson is "quietly confident" this will be her year.
The One Nation founder has spent almost two decades trying to mount her political comeback after losing her seat of Oxley in 1998 and political watchers say this year is her best chance.
A senior Labor strategist says the Turnbull government's voting reforms and the double-dissolution election could see Ms Hanson nab a Queensland senate spot.
With all 12 of the state's senate seats up for grabs, Ms Hanson only needs 7.75 per cent of the vote to be elected and the strategist says realistically she could get across the line with around four per cent of the vote.
He said the first 10 Senate spots would very likely be taken by the LNP, Labor and the Greens, but the final two spots were wide open.
"This new system means that the last two spots are really unpredictable," he told AAP.
"I think there's a big opportunity for her."
Ms Hanson told Nine's Today program on Tuesday she was "quietly confident" of being elected.
"But I don't take it for granted. I've been at it for many years now."
She also claimed dissatisfaction with the major parties meant One Nation candidates were serious contenders in every sate.
"I've been out speaking to the grassroots Australians ... they don't believe the political parties have listened to them.
"They have taken them for granted too long."
Griffith University political lecturer Paul Williams says the far-right politician has about an even chance of snatching the 12th Queensland Senate spot, with only independent senator Glenn Lazarus and Nick Xenophon Team's Suzanne Grant potentially standing in her way.
"I'm tipping her chances of getting that 12th spot at close to 50-50, she's as good a chance as any of the other frontrunners to take that spot, like Glenn Lazarus or a Xenophon candidate," he told AAP.
But Mr Williams said Ms Hanson would probably only be able to score the spot on her primary vote and wouldn't be able to count on a strong flow of preferences.
"Her primary vote will be pretty strong I would have thought, but she won't get too many preferences," he said.
"Historically most people put her last."
The Courier Mail reports Ms Hanson is planning a scare campaign based on opposition to refugees and foreign investment, and will claim her past complaints and predictions about immigration have come true.
Ms Hanson was the member for the Queensland seat of Oxley from 1996 to 1998 and became a hero of the far right with claims Australia was in danger of being "swamped by Asians".
She has been a regular candidate in state and federal elections in the past two decades, and came within 0.3 per cent of winning the outback seat of Lockyer in the 2015 Queensland election.
