The club have taken advantage of a gap in the busy Old Trafford schedule to move their Women's team's important match against the Hammers there from Leigh Sports Village.
Man United coach Casey Stoney lamented the lack of fans for the momentous occasion but hailed the progress nonetheless.
“Playing at Old Trafford will obviously be a special moment in the history of this team and it’s a fantastic opportunity to showcase the women’s game, which has seen huge growth over the last few years," Stoney said.
"We, of course, will miss our fans. They are such an important part of this club and we have felt their amazing support from afar throughout the season.
"We are all eager to get them back in the stands as soon as possible and hope that there will be many more opportunities to play at Old Trafford in the future.”
Collette Roche, the club's COO said: “We are thrilled to be hosting our women’s team at Old Trafford.
"The international break this month created a gap in this season’s relentless programme at the stadium and we all agreed that this was the right time to welcome Casey and her squad to Old Trafford.
Next year will see Old Trafford host the England Women's team in the UEFA Women's EURO 2022 opener.
